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目的观察腔内微波热疗加放射治疗对老年宫颈癌的临床疗效。方法收集我院2002年~2006年诊治的老年宫颈癌患者共40例。其中腔内微波热疗加放射治疗组20例,单纯放射治疗组20例。两组放射治疗方法相同,均采用8Mv-X线全盆腔外照射DT30Gy,盆腔四野DT20Gy,加192Ir高剂量率腔内后装治疗,A点DT42Gy。热疗采用915MHz微波热疗仪,腔内加温43℃~45℃,每次45 min,每周1~2次,共7~10次。结果在肿瘤局部控制率、治疗后CD4/CD8比值、自然杀伤细胞数、2年肿瘤无进展生存率及3年生存率等方面,热疗加放射治疗组均优于单纯放射治疗组,骨髓抑制及放射性直肠炎发生率热疗加放射治疗组明显低于单纯放射治疗组,差异均具有统计学意义(P<0.05)。结论腔内微波热疗联合放射治疗能提高老年宫颈癌患者的近期及远期疗效,不良反应小。
Objective To observe the clinical effect of intracavitary microwave hyperthermia and radiation therapy on elderly patients with cervical cancer. Methods A total of 40 elderly patients with cervical cancer who were diagnosed and treated in our hospital from 2002 to 2006 were collected. Among them, 20 cases were treated with microwave hyperthermia and radiation in the cavity and 20 cases were treated with radiotherapy alone. Radiotherapy methods were the same in both groups, all using 8Mv-X line external pelvic irradiation DT30Gy, pelvic four fields DT20Gy, plus 192Ir high dose rate endovascular treatment, A point DT42Gy. Hyperthermia using 915MHz microwave hyperthermia apparatus, cavity heating 43 ℃ ~ 45 ℃, each 45 min, 1 or 2 times a week, a total of 7 to 10 times. Results The local control rate of tumor, the ratio of CD4 / CD8 after treatment, the number of natural killer cells, the 2-year progression-free survival rate of tumor and the 3-year survival rate were significantly higher than those in radiotherapy alone group and bone marrow suppression group And the incidence of radiation proctitis in hyperthermia plus radiation group were significantly lower than those in radiotherapy alone group, the differences were statistically significant (P <0.05). Conclusion Intra-cavity microwave hyperthermia combined with radiotherapy can improve the short-term and long-term curative effect of elderly patients with cervical cancer with little adverse reactions.