Objective: We evaluated (Whole-Body Diffusion Weighted Imaging, WB-DWI) application in bone metastasis. Methods: WB-DWI with GE 1.5T MR/I was performed on 10 healthy volunteers and 35 patients. WB-DWI and ECT was performed in all 35 patients. Using WB-DWI for detecting bone metastasis and compared them with that of ECT. Results: Background was suppressed in WB-DWI, fat, muscle, vessels and liver appeared same as background. Skeleton showed medium or slightly lower signal. Lymph nodes, some glandular organs, kidneys displayed medium signal. Spleen, testicle, brain tissue were low signal. Bladder, gallbladder were depicted as low signal because of “T2 through”. Bone metastasis were multitude and inequality of size, punctiform, nodosity, column low intensity. Concordance between WB-DWI and ECT was seen in 4 cases. WB-DWI displayed 1 bone metastasis on skull, 46 on rib and sternum, 3 on scapula, 4 on extremities, 83 on vertebral, 36 on pelvic bone. ECT showed 2 bone metastasis on skull, 62 on rib and sternum, 7 on scapula, 9 on extremities, 64 on vertebral, 19 on pelvic bone. WB-DWI was 74% for bone metastasis on rib and sternum, ECT was 77%, 53% for vertebral and pelvic bone. All of the focus were statistics analyses, P < 0.05. Total probability distribution inequality if metastasis on different positions. Conclusion: WB-DWI was an effective imaging technology for screening bone metastasis. Methods: WB-DWI with GE 1.5T MR / I was performed on 10 healthy volunteers and 35 patients. WB-DWI and ECT was performed In all 35 patients. Using WB-DWI for detecting bone metastasis and comparing them with that of ECT. Results: Background was suppressed in WB-DWI, fat, muscle, vessels and liver had the same as background. Skeleton showed medium or slightly lower signal Spleen, testicle, brain tissue were low signal. Bladder, gallbladder were drawn as low signal because of “T2 through.” Bone metastasis were multitude and inequality of size, punctiform , on nodosity, column low intensity. Concordance between WB-DWI and ECT was seen in 4 cases. WB-DWI displayed 1 bone metastasis on skull, 46 on rib and sternum, 3 on scapula, 4 on extremities, 83 on vertebral, 36 on pelvic bone. ECT showed 2 bone metastasis on skull, 62 on rib and sternum, 7 on scapula, 9 on extremities, 64 on vertebral, 19 on pelvic bone. WB-DWI was 74% for bone metastasis on rib and sternum, ECT was 77%, 53% for vertebral and pelvic bone. All of the focus were statistics analyzes, P <0.05. Total probability distribution inequality if metastasis on different positions. Conclusion: WB-DWI was an effective imaging technology for screening bone metastasis.