microRNAs(miRNAs)是一类在转录后水平调控基因表达的内源性非编码小RNA分子。miRNAs具有癌基因与抑癌基因的功能,参与肿瘤细胞的增殖、粘附、侵袭、转移和肿瘤血管形成等过程。miRNAs可调节肿瘤细胞转移表型,主要通过改变肿瘤细胞黏附力、侵袭力与迁移力。本文重点介绍调节肿瘤细胞转移表型相关miRNAs及其作用的分子机制,以便为肿瘤转移的研究提供新思路。 MicroRNAs (miRNAs) are a class of endogenous non-coding small RNA molecules that regulate gene expression at the post-transcriptional level. MiRNAs have the functions of oncogenes and tumor suppressor genes involved in the proliferation, adhesion, invasion, metastasis and tumor angiogenesis of tumor cells. miRNAs can regulate tumor cell metastasis phenotype, mainly by changing tumor cell adhesion, invasion and migration. This article focuses on the molecular mechanisms that regulate the miRNAs involved in the metastatic phenotype of tumor cells and their roles in order to provide new insights into tumor metastasis.