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目的观察养胃颗粒对大鼠脏器的毒性及毒性程度。方法将SD大鼠随机分为4组:对照组(给予等量0.3%羧甲基纤维素钠)、3个剂量(69.0,34.5,6.9g·kg-1)养胃颗粒组,每天1次,连续灌胃给药90 d。停药后,测定脏器系数,透射电镜下观察超微结构的变化。结果给药期间,部分脏器系数有微小变化;停药后,上述异常变化指标均恢复正常。给药期及恢复期,经重要脏器病理组织检查,均未发现明显异常。结论养胃颗粒对大鼠主要脏器未见明显毒性反应,长期服用安全。
Objective To observe the toxicity and toxicity of Yangwei granule to rats’ organs. Methods SD rats were randomly divided into 4 groups: control group (given the same amount of 0.3% sodium carboxymethyl cellulose), 3 doses (69.0,34.5,6.9g · kg-1) Yangwei particles group once daily , Continuous oral administration of 90 d. After stopping the drug, the organ coefficient was measured and the ultrastructural changes were observed under transmission electron microscope. Results During the administration, some of the organ coefficients changed slightly; after the drug was stopped, the abnormal changes of the indicators returned to normal. Dosing and recovery period, the pathological examination of vital organs, found no significant abnormalities. Conclusion Yangwei granule has no obvious toxic reaction to the main organs of rats and is safe for long-term use.