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目的通过与口服避孕药(OC)治疗多囊卵巢综合征(PCOS)不孕患者的临床疗效比较,探讨超声下未成熟卵泡抽吸术(IMFA)治疗PCOS不孕患者的有效性和可行性。方法研究组(32例)在阴道超声引导下进行40个周期的IMFA,对照组(46例)于月经第5天口服达英-35避孕药,比较两组治疗前后的内分泌水平变化、卵巢基础窦卵泡数及卵巢体积大小的变化、两组治疗后月经改善及排卵恢复情况。结果与对照组相比,研究组睾酮(T)、黄体生成素(LH)和卵泡刺激素(FSH)水平穿刺后明显降低,差异有统计学意义;84.4%(27/32)的患者基础窦卵泡计数降至10个以下,卵巢体积明显缩小;59.4%(19/32)的患者术后一个月月经周期缩短,43.8% (14/32)的患者恢复排卵。结论IMFA和OC均能够减少PCOS患者基础窦卵泡计数和卵巢体积,并改善其内分泌状况,但IMFA在改善月经和排卵情况方面更优于OC,是治疗PCOS不孕的又一有效可行的辅助生育治疗途径。
Objective To compare the clinical efficacy of oral contraceptives (OC) with infertility patients with polycystic ovary syndrome (PCOS) to explore the effectiveness and feasibility of ultrasound immature follicle aspiration (IMFA) in the treatment of infertility patients with PCOS. Method group (32 cases) under the guidance of vaginal ultrasound 40 cycles of IMFA, the control group (46 cases) on the 5th day of menstruation orally Ying Ying -35 contraceptives, compared two groups before and after treatment of endocrine levels, ovarian base Antral follicles and ovarian volume changes in both groups after treatment to improve menstrual and ovulation recovery. Results Compared with the control group, the levels of testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the study group decreased significantly after puncturing, with significant difference; 84.4% (27/32) Ovarian volume was significantly reduced after the follicle count was reduced to less than 10; the menstrual cycle of 59.4% (19/32) patients was shortened one month after operation, and 43.8% (14/32) of patients regained their ovulation. Conclusion Both IMFA and OC can reduce basal antral follicle count and ovarian volume in PCOS patients and improve their endocrine status. However, IMFA is superior to OC in improving menstruation and ovulation, and is another effective and viable assisted fertility for PCOS infertility Therapeutic approach.