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目的对新疆HIV-1亚型流行形势做一调查分析,为新疆艾滋病防治提供科学依据。方法选择新疆感染者人数众多的乌鲁木齐市、伊宁市等各县市2009和2010年新确认的409份样本进行RNA提取、扩增、测序、序列比对及系统树的建立的分析,了解新疆HIV-1亚型的流行形式,同时对这些患者做了一个简单的流行病学的调查,分析了性别、传播形式等因素对HIV亚型的影响因素。结果新疆HIV-1主要以CRF07-BC为主要流行亚型,亚型比较单一,新疆HIV的传播形式由主要是吸毒传播转为性传播,但调查分析结果显示传播途径的改变并未对亚型有大的影响。结论新疆艾滋病感染人数虽然较多,但其亚型单一,流行形式并无明显变化,提示利于后期防治工作。
Objective To investigate the epidemic situation of HIV-1 subtype in Xinjiang and provide a scientific basis for AIDS prevention and control in Xinjiang. Methods A total of 409 samples newly identified in Urumqi, Yining and other counties and cities in Xinjiang in 2009 were selected for analysis of RNA extraction, amplification, sequencing, sequence alignment and phylogenetic tree analysis to understand Xinjiang HIV-1 subtypes of the epidemic forms, at the same time to these patients a simple epidemiological survey, analysis of gender, forms of transmission and other factors on the impact of HIV subtypes. Results HIV-1 in Xinjiang mainly used CRF07-BC as the main epidemic subtypes. The subtype of HIV-1 in Xinjiang was single. The transmission form of HIV in Xinjiang mainly changed from drug-to-sex transmission. However, the investigation and analysis showed that transmission of HIV- Have a big impact. Conclusion Although the number of HIV infection in Xinjiang is relatively high, its subtypes are single and there is no obvious change in its epidemic form, suggesting that it is conducive to the prevention and treatment in the later stage.