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作者将20例急性非淋巴细胞白血病(及完成化疗后)的骨髓活检标本,用低温塑料包埋,作碱性磷酸酶(AlPase)反应。结果为:在多囊性前脂肪细胞质膜内显示有AlPase,这种细胞在化疗后1周时最为突出。其形态自园形到分枝和狭长,并显示各期脂肪积贮,在较小的前脂肪细胞中AlPase活性强,中间型为中等活性,超过120μm直径的前脂肪细胞和单囊的脂肪细胞则阴性。亦即成熟程度增加时,酶的活性降低。在治疗前白血病骨髓中成熟脂肪细胞缺如或极少,这种细胞在完成化疗后1月时数量最多,在3例
Bone marrow biopsy specimens from 20 patients with acute non-lymphocytic leukemia (and after chemotherapy) were embedded in low-temperature plastic and reacted with AlPase. As a result, AlPase was displayed in the plasma membrane of the polycystic preadipocyte, which was most prominent at 1 week after chemotherapy. Its morphology is circular to branched and elongated, and shows accumulation of various phases of fat, AlPase activity in smaller preadipocytes, intermediate activity of moderately active, preadipocytes more than 120 μm in diameter and monocytic adipocytes Negative. That is, when the degree of maturity increases, the activity of the enzyme decreases. Mature adipocytes in the leukemia bone marrow were absent or infrequently treated before treatment, with the highest number of cells at 1 month after completion of chemotherapy and in 3