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胃肠道是消化吸收营养物质的主要场所,各种应激损伤对机体胃肠道正常黏膜组织结构造成破坏,从而降低胃肠道对营养物质的消化和吸收。多肽类生长因子参与肠上皮生长调控,并对肠黏膜损伤后的再生修复有促进作用,但其作用缺乏特异性,常会引起机体的不良反应。胰高血糖素样肽2(GLP-2)有明显促进肠道对营养物质的吸收作用,且具有特异性。GLP-2通过与其受体结合而实现其生物学作用,但作用机制目前尚不十分清楚。GLP-2通过直接促进肠上皮细胞的增殖、抑制其凋亡,或通过分布于肠内其他部位的GLP-2R间接促进正常小肠的生长和病理肠黏膜的恢复。
Gastrointestinal tract is the main site for digestion and absorption of nutrients, a variety of stress damage to the body’s normal gastrointestinal mucosal tissue damage, thereby reducing the digestion and absorption of nutrients in the gastrointestinal tract. Peptide growth factor is involved in the regulation of intestinal epithelial growth, and promote the regeneration and repair of intestinal mucosal injury, but its role in the lack of specificity, often cause the body’s adverse reactions. Glucagon-like peptide 2 (GLP-2) significantly enhances intestinal absorption of nutrients and is specific. GLP-2 binds to its receptor to achieve its biological role, but the mechanism of action is not yet clear. GLP-2 promotes the growth of normal small intestine and the recovery of pathological intestinal mucosa indirectly by directly promoting the proliferation of intestinal epithelial cells, inhibiting their apoptosis, or indirectly through GLP-2R distributed in other parts of the intestine.