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目的探讨刺络放血疗法治疗慢性阻塞性肺疾病急性加重期(AECOPD)的效果及机制。方法将70例AECOPD患者随机分为治疗组和对照组,每组35例。两组均给予常规治疗,治疗组加用刺络放血治疗,两组疗程均为14 d,观察两组临床疗效及凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)的变化。结果治疗组总有效率为97.1%,对照组总有效率为80.0%,治疗组疗效优于对照组(P<0.05)。治疗后治疗组患者的APTT、FIB、D-D水平均明显改善(P<0.05),而对照组治疗前后上述指标未有变化(P>0.05)。结论刺络放血疗法能改善AECOPD患者的凝血与抗凝功能,提高治疗AECOPD的效果。
Objective To investigate the effect and mechanism of pricking bloodletting therapy on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Seventy patients with AECOPD were randomly divided into treatment group and control group, 35 cases in each group. The two groups were given conventional treatment, the treatment group plus pricking blood therapy, the two groups of treatment were 14 d, the clinical efficacy and prothrombin time (PT), activated partial thromboplastin time (APTT), fibrin (FIB), D-dimer (DD) changes. Results The total effective rate was 97.1% in the treatment group and 80.0% in the control group. The curative effect in the treatment group was better than that in the control group (P <0.05). The levels of APTT, FIB and D-D in treatment group were significantly improved after treatment (P <0.05), while those in control group did not change before and after treatment (P> 0.05). Conclusion Pricking blood therapy can improve blood coagulation and anticoagulation in patients with AECOPD and improve the efficacy of AECOPD.