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目的探讨胃肠道间质瘤(GIST)的临床治疗及其预后影响因素。方法回顾分析2008年1月-2015年12月38例经手术治疗GIST患者的临床病例资料,比较相关因素对患者预后的影响。结果38例患者中男27例,女11例,中位年龄56.5岁,肿瘤位于胃24例,小肠9例,食管1例,结直肠4例,患者随访时间1-60个月,随访期间5例(13.3%)发生术后复发和(或)转移。Logistic回归分析显示,肿瘤部位、大小、肿瘤是否破裂和核分裂像与GIST患者预后有关。COX回归模型显示,肿瘤部位和核分裂像是影响GIST患者预后的独立因素(P<0.05)。结论 GIST缺乏特异性临床表现,肿瘤部位和核分裂像是影响GIST患者预后的独立危险因素。
Objective To investigate the clinical treatment of gastrointestinal stromal tumors (GIST) and its prognostic factors. Methods The clinical data of 38 patients with GIST surgically treated from January 2008 to December 2015 were retrospectively analyzed. The influence of related factors on the prognosis of patients was compared. Results There were 27 males and 11 females with a median age of 56.5 years. The tumors were located in the stomach in 24 cases, the small intestine in 9 cases, the esophagus in 1 case and the colorectum in 4 cases. The patients were followed up for 1-60 months and followed up for 5 Cases (13.3%) had postoperative recurrence and / or metastasis. Logistic regression analysis showed that tumor location, size, tumor rupture and mitosis were related to the prognosis of GIST patients. COX regression model showed that tumor location and mitotic figures were independent prognostic factors in GIST patients (P <0.05). Conclusion GIST lack of specific clinical manifestations, tumor sites and mitotic figures are independent risk factors affecting the prognosis of GIST patients.