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目的探讨前列腺癌病人血清PSA、f/tPSA(血清游离PSA与总PSA的比值)与前列腺癌Gleason评分、临床分期的相关性。方法查阅我院1998年1月～2005年6月归档的前列腺癌病历资料,建立临床资料数据库,对归档病理切片进行Gleason评分。采用Spearman等级相关分析,分析血清PSA、f/tPSA与前列腺癌Gleason评分、临床分期的关系。结果269例前列腺癌中,前列腺癌PSA值与Gleason评分呈正相关(r=0.361,P<0.01),与前列腺癌临床分期呈正相关(r=0.586,P<0.01);f/tPSA与Gleason评分有弱负相关(r=-0.128,P=0.035),与前列腺癌临床分期呈负相关(r=-0.226,P<0.01)。结论血清PSA、f/tPSA与前列腺癌预后密切相关的指标临床分期和Gleason评分有关。
Objective To investigate the correlation between serum PSA, f / tPSA (ratio of serum free PSA to total PSA) and Gleason score of prostate cancer and clinical stage in patients with prostate cancer. Methods The medical records of prostate cancer filed from January 1998 to June 2005 in our hospital were reviewed. The database of clinical data was established and the Gleason score of the pathological sections was archived. Spearman rank correlation analysis was used to analyze the relationship between serum PSA, f / tPSA and Gleason score and clinical stage of prostate cancer. Results In 269 cases of prostate cancer, the PSA value was positively correlated with the Gleason score (r = 0.361, P <0.01), and positively correlated with the clinical stage of prostate cancer (r = 0.586, P <0.01) (R = -0.128, P = 0.035), which was negatively correlated with the clinical stage of prostate cancer (r = -0.226, P <0.01). Conclusion Serum PSA, f / tPSA and prognosis of prostate cancer are closely related to the clinical stage and Gleason score.