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目的对2型糖尿病患者有胰岛素抵抗(IR)一级亲属进行生活方式干预后,观察其胰岛β细胞功能及胰岛素敏感性的变化及IR改善情况。方法将T2DM家系非DM但具有明显IR的一级亲属46人分为生活方式干预组与非干预组,定期观察各项指标,随访2年。结果干预组经生活方式干预后BMI降低,2hPG、TG水平降低(P<0.05),高胰岛素水平改善(P<0.01),IR程度明显减轻(P<0.01)。结论干预可以改善胰岛素敏感性,减轻IR,对减少糖尿病的发生,减少大血管并发症的形成具有积极的意义。
Objective To investigate the changes of pancreatic β-cell function and insulin sensitivity and the improvement of IR after lifestyle intervention in first-degree relatives of type 2 diabetic patients with insulin resistance (IR). Methods 46 non-DM but significant IR first-degree relatives of T2DM families were divided into lifestyle intervention group and non-intervention group. The indexes were observed regularly for 2 years. Results After intervention, the BMI decreased, the level of PGE2 decreased (P <0.05), the level of HOMI improved (P <0.01), and the degree of IR decreased significantly (P <0.01). Conclusion Intervention can improve insulin sensitivity and reduce IR, which has a positive effect on reducing the incidence of diabetes and reducing the formation of macrovascular complications.