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创伤愈合是一个复杂的生物学过程,涉及炎症细胞,修复细胞、细胞外基质以及细胞因子之间的相互作用。传统将这一过程分为炎症期、增值期、组织重构三个相互重叠的时期。细胞因子是一类对细胞生长、分化有明显调控作用的小分子生物活性多肽,是细胞与细胞外基质间重要的信号传导物。多种生长因子被释放到伤口部位被认为是创伤愈合所必需的。本文就细胞因子对创伤愈合的促进作用、细胞因子相互之间的协同作用,以及应用前景作以概述。
Wound healing is a complex biological process involving the interaction of inflammatory cells, repair cells, extracellular matrix and cytokines. Traditionally, this process is divided into inflammatory phase, value-added phase, organizational restructuring three overlapping periods. Cytokines are a class of small molecule bioactive peptides that play a significant regulatory role in cell growth and differentiation and are important signal transducers between cells and extracellular matrix. Release of various growth factors to the wound site is considered necessary for wound healing. This article summarizes the role of cytokines in promoting wound healing, the synergistic effect between cytokines and their potential applications.