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下丘脑是调节摄食行为和能量平衡的关键部位。脂肪组织分泌的leptin(瘦素 )通过下丘脑内侧基底部的受体 ,正调神经肽YmRNA、负调阿黑皮素原 (POMC)mRNA的表达 ,抑制食欲和进食 ;而下丘脑外侧部的黑素细胞凝聚素、增食欲素 (orexin)则刺激进食。两者共同调控能量自稳态 ,参与肥胖的调节。进食促进因子和抑制因子亦相互作用构成下丘脑能量调节网络 ,探讨网络构成及作用的分子机制是未来研究肥胖发生的方向。
The hypothalamus is a key site for regulating feeding behavior and energy balance. Adipose tissue-secreted leptin (leptin) regulates neuropeptide Y mRNA through the receptors in the medial basal ganglia of the hypothalamus, negatively regulates the expression of pro-opiomelanocortin (POMC) mRNA, suppresses appetite and eating, whereas the hypothalamus Melanocortin, orexin, stimulates eating. The two jointly regulate energy homeostasis, involved in the regulation of obesity. Eating and promoting factors and inhibitors also interact to form the hypothalamic energy regulation network to explore the molecular mechanism of network formation and role in the future study of obesity occurs.