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目的观察胎盘多肽注射液与化疗药物联合治疗中晚期恶性肿瘤的有效性和安全性。方法2007年10月～2008年11月,78例中晚期恶性肿瘤患者入组,按数字法随机分为胎盘多肽联合化疗的治疗组(38例)和单纯化疗的对照组(40例),原发肿瘤相同患者的化疗方案相同,治疗组化疗开始时予胎盘多肽8ml加入0.9%氯化钠注射液250ml中静滴,连用14天,21天为1周期,共用4～6周期。结果治疗组和对照组的近期疗效分别为47.4%和45%(P>0.05),治疗组治疗后的生活质量(QOL)评分及体力状况(KPS)评分较对照组增加(P<0.05),T细胞亚群及NK细胞活性明显高于对照组(P<0.05),白细胞下降程度、恶心呕吐、口腔粘膜炎及外周神经毒性等毒副作用发生率明显低于对照组(P<0.05),其它血液学毒性及腹泻、脱发、肝功能异常等毒副作用两组发生率相似(P>0.05)。结论胎盘多肽注射液与化疗药物联合,对中晚期恶性肿瘤有一定的辅助治疗作用,值得临床进一步推广。
Objective To observe the efficacy and safety of combination of placental peptide injection and chemotherapy in the treatment of advanced malignant tumors. Methods From October 2007 to November 2008, 78 patients with advanced malignant tumor were enrolled and randomly divided into treatment group (38 cases) and chemotherapy alone group (40 cases) treated with placental peptide combined with chemotherapy The same chemotherapy in patients with the same tumor chemotherapy, the treatment group chemotherapy to the placental peptide 8ml 0.9% sodium chloride injection 250ml intravenous infusion, once every 14 days, 21 days for a cycle, sharing 4 to 6 cycles. Results The curative effect of the treatment group and the control group were 47.4% and 45% respectively (P> 0.05). The QOL score and KPS score of the treatment group were significantly higher than those of the control group (P <0.05) (P <0.05). The incidence of leukopenia, nausea and vomiting, oral mucositis and peripheral neurotoxicity were significantly lower than those in the control group (P <0.05). Other Hematological toxicity and diarrhea, hair loss, liver dysfunction and other side effects were similar (P> 0.05). Conclusion Placenta polypeptide injection combined with chemotherapeutic drugs has certain adjuvant therapeutic effect on advanced malignant tumors and deserves further clinical promotion.