皮质下缺血性脑血管病(SIVD)是指脑部小血管病理性功能改变,导致皮质下血液灌注不足,造成脑细胞多发性腔隙性梗死和脑白质病变所引起的一系列脑部损伤的症状[1]。患者发病时症状往往不典型,常伴有轻微的神经系统症状[2],一般临床诊断检测的敏感性不高,患者常常错过治疗的最佳时期。SIVD患者一般临床症状多为认知功能障碍、运动功能下降、情绪改变、日常生活能力减退等[3],SIVD病人病程中较易出现抑郁 Subcortical ischemic cerebrovascular disease (SIVD) refers to the pathological changes of small blood vessels in the brain, leading to inadequate perfusion of blood under the cortex, resulting in a series of brain damage caused by multiple cerebral lacunar infarcts and white matter lesions Symptoms [1]. Symptoms are often atypical in patients with onset, often accompanied by minor neurological symptoms [2], the general clinical diagnostic test is not sensitive, patients often miss the best period of treatment. SIVD patients are mostly clinical symptoms of cognitive dysfunction, decreased motor function, emotional changes, decreased ability of daily life [3], SIVD patients prone to depression in the course of disease