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测定了替硝唑对临床分离的148株厌氧菌和2株标准株的MIC,确定替硝唑对革兰氏阴性厌氧菌活性最强,其MIC为0.062~1mg/L,它们对梭菌的MIC为0.25~0.5mg/L,对革兰氏阳性无芽孢厌氧杆菌,除了真杆菌MIC为4mg/L外,抗菌活性较低,其MIC为大于64mg/L,对厌氧球菌也有相当的活性,其MIC为0.25~1.0mg/L。
The MICs of 148 anaerobic and 2 standard isolates isolated from clinical isolates of tinidazole were determined. The results showed that tinidazole was the most active against Gram-negative anaerobic bacteria with MIC of 0.062 ~ 1 mg / L MIC for Clostridium was 0.25-0.5 mg / L. For Gram-positive spore-forming anaerobic bacilli, except for the eubacterium MIC being 4 mg / L, the antibacterial activity was lower and its MIC was more than 64 mg / L. Anaerobic bacteria also have considerable activity, the MIC was 0.25 ~ 1.0mg / L.