补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。Cfb基因敲除大鼠[Cfb(-/-)]出现糖耐量及胰岛素敏感性改 Complement factor B (CFB) levels are elevated in adipose tissue and serum of patients with type 2 diabetes mellitus and cardiovascular disease, but their causal relationship with the pathogenesis of the disease is not clear. Spontaneous hypertensive rats (spontaneously hypertensive rats, SHR) adipose tissue and serum CFB also increased. To clarify the role of CFB in the metabolic syndrome, researchers knocked out the Cfb gene in SHR. Cfb knockout rats [Cfb (- / -)] impaired glucose tolerance and insulin sensitivity