论文部分内容阅读
肿瘤干细胞(tumor/cancer stem cells)理论认为是肿瘤组织中存在数量极少、具有干细胞特征的细胞亚群,该细胞亚群具有自我更新和分化潜能,可能是肿瘤启动、生长、转移和复发的根源。肿瘤干细胞可以自我克隆形成子代致瘤性干细胞,同时分化出具有不同表型、非致瘤性的肿瘤细胞,后者经过短暂分化最终死亡[1]。40多年前,有学者提出组织特异性干细胞是肿瘤发生的起源细胞[2]。20世纪60年代,人们从体外克隆培养获得的
Tumor stem cells (tumor/cancer stem cells) theory holds that there are a very small number of subpopulations of stem cells in tumor tissues. This subpopulation of cells has self-renewal and differentiation potential and may be tumor initiation, growth, metastasis and recurrence. source. Cancer stem cells can be self-cloned to form progeny oncogenic stem cells, and differentiate into tumor cells with different phenotypes and non-tumorigenicity, which eventually die after transient differentiation [1]. More than 40 years ago, some scholars proposed that tissue-specific stem cells are the origin of tumors [2]. In the 1960s, people obtained from in vitro clonal culture