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应用免疫组织化学方法对３６例喉鳞癌患者的ｎｍ２３基因产物／核苷二磷酸激酶（ｎｍ２３／ＮＤＰＫ）进行检测。结果：喉鳞癌中ｎｍ２３／ＮＤＰＫ表达的阳性率为６９．４％（２５／３６）；随着肿瘤的增大及淋巴结转移的出现，ｎｍ２３表达程度降低，Ｔ１－２病变高于Ｔ３－４病变；Ⅰ～Ⅱ期喉癌高于Ⅲ～Ⅳ期喉癌；无颈淋巴结转移者高于颈淋巴结转移者（Ｐ＜０．０５）。ｎｍ２３／ＮＤＰＫ表达与肿瘤生长部位及病理分级无关。表明ｎｍ２３基因低表达可能是肿瘤进展和颈淋巴结转移的相关因素。
Immunohistochemistry was used to detect nm23 / NDPK in 36 cases of laryngeal squamous cell carcinoma. Results: The positive rate of nm23 / NDPK in laryngeal squamous cell carcinoma was 69.4% (25/36). With the increase of tumor size and lymph node metastasis, the expression of nm23 / Lesions were higher in stage Ⅰ-Ⅱ laryngeal cancer than in stage Ⅲ-Ⅳ laryngeal cancer; those with no lymph node metastasis were significantly higher than those with cervical lymph node metastasis (P <0.05). nm23 / NDPK expression and tumor growth sites and pathological grade has nothing to do. The results suggest that the low expression of nm23 gene may be related to tumor progression and cervical lymph node metastasis.