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用2次移植法测定不同剂量硫芥sc小鼠骨髓CFU_0的自我更新和分化功能。硫芥小剂量(15mg/kg)杀伤下,约半数剩余的CFUs的更新潜能仍保持正常。加大硫芥剂量(25mg/kg)使CFUs严重耗竭,残存的CFUs仅为正常值的8％,但其自我更新能力却高达正常的2.5倍,并历时30d而不减退。在上述剂量作用下,不论近期或远期测定,残存的CFUs主要表现为向粒系分化的提高和向巨核系分化的减少。硫芥作用下残存的CFUs具有良好的自我更新功能,是其染毒后造血功能得以迅速恢复的根本原因。然而,造血干细胞向巨核系分化的相对减少,可能影响血小板的生成量是应该引起注意的问题。
The self-renewal and differentiation of bone marrow CFU_0 in different doses of sulfur mustard sc mice were determined by two-times transplantation. Approximately half of the remaining CFU renewal potential remains intact with a low dose of sulfur mustard (15 mg / kg). Increased sulfur mustard dose (25mg / kg) CFU serious depletion of residual CFUs only 8% of normal, but its self-renewal capacity was as high as 2.5 times the normal and lasted 30d without diminished. Under these doses, residual CFUs are mainly manifested as an increase in granulocyte differentiation and a decrease in differentiation to megakaryocytes, both in the immediate and long-term determinations. Residual CFUs under the action of sulfur mustard have a good self-renewal function, which is the fundamental reason for rapid recovery of hematopoietic function after being poisoned. However, the relative reduction of hematopoietic stem cells to megakaryocytic differentiation, which may affect the production of platelets, is a cause for concern.