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本文研究了益母草注射液对小鼠血小板内 cAMP、cGMP 以及大鼠颈动脉壁PGI_2样物质的影响。证明益母草能使小鼠血小板内 cAMP 含量升高,显著抑制血小板聚集,但对大鼠血管壁 PGI_2样活性物质无影响。其作用机制很可能是药物具有抑制磷酸二酯酶活性,或通过激素等起作用。
In this paper, the effects of Leonurus injection on cAMP, cGMP, and PGI2-like substances in rat carotid arterial wall were investigated. It was proved that Motherwort could increase cAMP content in platelets of mice and inhibit platelet aggregation significantly, but it had no effect on PGI2-like active substances in the blood vessel wall of rats. The mechanism of action is likely to be that the drug has inhibited phosphodiesterase activity, or acts through hormones and the like.