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Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or-2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde-hyde or nicotinic acid by two different synthetic methods respectively. The preliminary bioactive tests indicate som compounds exhibit potent relaxing effect on endothelial cells, comparable to Ach or arecoline.