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目的 评价雷帕霉素药物涂层支架 (CYPHER ,Cordis)对冠心病治疗效果的初步观察。方法 我院在 2 0 0 2年 10月至 2 0 0 3年 10月的 16例冠心病患者置入CYPHER支架 ,病变长度 18～ 35mm ,术前病变狭窄程度 (90±9 0 ) % ;心血管直径 (2 75～ 3 5mm)。观察药物涂层支架的手术成功率、术中并发症、住院期间及 1年内随访期间的心绞痛、再次血管重建、支架内血栓形成等发生。结果 手术即刻成功率 10 0 % ,术后造影病变残余狭窄 0 % ,支架完全覆盖病变 ,支架近远端无夹层 ,血流TIMI 3级。临床随访 1年13例患者心绞痛消失 ,12例术后 6个月复查冠脉造影 ,无支架内血栓形成 ,无血管再狭窄。结论 雷帕霉素药物涂层支架用于冠心病治疗是安全的 ,临床效果明显优于冠脉普通支架置入
Objective To evaluate the therapeutic effect of rapamycin-coated stent (CYPHER, Cordis) on coronary heart disease. Methods Sixteen patients with coronary heart disease from October 2002 to October 2003 were enrolled in the CYPHER stent. The length of the disease was 18-35mm and the preoperative stenosis was 90 ± 90%. Heart Blood vessel diameter (2 75 ~ 3 5mm). Surgical success rate, intraoperative complications, angina pectoris during hospitalization and follow-up within 1 year, revascularization and stent thrombosis were also observed. Results The immediate success rate of surgery was 100%. The residual stenosis of postoperative angiography was 0%. The stent completely covered the lesion, and there was no dissection in the proximal and distal ends of the stent. The TIMI level of blood flow was 3 grade. One year after clinical follow-up, angina pectoris disappeared in 13 patients and coronary angiography was retrospectively performed in 12 patients at 6 months after operation. No stent thrombosis and no vascular restenosis were observed. Conclusion Rapamycin-coated stent is safe for coronary heart disease and the clinical effect is better than that of coronary stent