考察了苯丙酮在手性胺膦配体与[IrHCl2(COD)]2组成的催化体系下不对称转移氢化合成(S)-(-)-1-苯基-1-丙醇的反应,通过正交实验考察了反应温度、n(底物)∶n(铱催化剂)、n(铱催化剂)∶n(手性配体)和碱用量对反应的影响。结果表明,在异丙醇中,利用该体系催化苯丙酮反应6 h后,反应转化率可达94.5%,对映选择性(ee)达96.0%。 The reaction of propanone with asymmetric transfer hydrogenation of (S) - (-) - 1-phenyl-1-propanol under the catalytic system consisting of chiral amine phosphine ligand and [IrHCl2 The effects of reaction temperature, n (substrate): n (iridium catalyst), n (iridium catalyst): n (chiral ligand) and base on the reaction were investigated by orthogonal experiments. The results showed that the reaction rate reached 94.5% and the enantioselectivity (ee) reached 96.0% after isopropanol was used to catalyze the reaction of propiophenone for 6 h.