先证者　男 ,44岁。因双手震颤 2 0年 ,伴四肢无力 6年入院。 2 0年前出现双手不自主颤动 ,偶有劳累后四肢无力 ,曾因甲状腺肿大 ,检测甲状腺功能 T3、T4偏高 ,诊断为“青春期甲状腺肿”,未治疗。 6年前 ,出现易疲劳 ,走 5 0 0 m左右便觉腰腿酸疼、双下肢无力 ,休息后缓解。就 The proband male, 44 years old. Due to tremor 20 years, accompanied by weakness six years hospitalization. 20 years ago involuntary hands vibration both hands, sometimes tired after extremities weakness, had thyroid enlargement, detection of thyroid function T3, T4 high, diagnosed as “adolescent goiter”, untreated. 6 years ago, appeared prone to fatigue, walk about 500m feel waist and leg aching, weakness of both legs, rest and ease. on