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目的分析系统性红斑狼疮(SLE)患者并发重症感染时外周血白细胞糖皮质激素受体(GCR)水平的变化及意义。方法 73例SLE患者分为重症感染组和非重症感染组,分别检测GCR水平,并与正常组对照。结果1.各组SLE活动指数及生化指标比较,重症感染组与非重症感染组、正常对照组比较,CRP明显增高,差异有统计学意义(P均<0.01);ALB、HGB明显减低,差异有统计学意义(P均<0.01)。重症感染组与非重症感染组比较,SLE活动指数明显增高(P<0.01)。非重症感染组与正常对照组比较,CRP明显增高,差异有统计学意义(P<0.01);ALB、HGB较对照组明显减低,差异有统计学意义(P均<0.01)。2.重症感染组和非感染组、正常对照组三组外周血白细胞GCR水平:重症感染组与非重症感染组、正常对照组比较,白细胞GCR水平均明显降低,差异有统计学意义(P均<0.01);其中,非重症感染组与正常对照组比较,白细胞GCR水平明显降低(P<0.01)。结论系统性红斑狼疮并发重症感染时血白细胞GCR水平明显减低,可进一步加重病情活动及治疗难度,测定SLE患者周围血白细胞GCR水平,有助于预测患者的病情、预后。
Objective To analyze the changes and significance of peripheral blood leukocyte glucocorticoid receptor (GCR) in patients with systemic lupus erythematosus (SLE) complicated with severe infection. Methods Seventy-three patients with SLE were divided into two groups: severe infection group and non-severe infection group. The levels of GCR were detected and compared with those in normal group. The results of SLE activity index and biochemical index of each group, severe infection group and non-severe infection group, the normal control group, CRP was significantly higher, the difference was statistically significant (P all <0.01); ALB, HGB was significantly lower, the difference There was statistical significance (all P <0.01). Compared with non-severe infection group, the SLE activity index in severe infection group was significantly higher (P <0.01). CRP was significantly higher in non-severe infection group than in normal control group (P <0.01). The ALB and HGB levels were significantly lower than those in control group (P <0.01). The GCR levels of peripheral blood leukocytes in severe infection group, non-infected group and normal control group were significantly lower than those in non-severe infection group and normal control group (P <0.05) <0.01). The GCR level of leukocytes in non-severe infection group was significantly lower than that in normal control group (P <0.01). Conclusions The GCR level of leukocytes in patients with systemic lupus erythematosus complicated by severe infection is significantly lower, which may further aggravate the disease activity and the difficulty of treatment. The determination of GCR levels in peripheral white blood cells of SLE patients is helpful to predict the patient’s condition and prognosis.