Nature 2015,523,445-450胺类化合物(碳氮键)是有机化学当中极其重要的一类化合物.目前,世界上超过95%的药物分子都含有氮原子.如何高效同时又高选择性地构筑含氮分子,是新药研发领域的重要课题.在构建碳氮键的方法中,碳基亲核试剂进攻亚胺当中的碳氮双键成键是种常见方法.若亚胺碳氮双键极性发生反转, Nature 2015,523,445-450 Amine compounds (carbon-nitrogen bonds) are one of the most important compounds in organic chemistry and currently contain over 95% of the drug molecules in the world containing nitrogen atoms. How to efficiently and simultaneously construct high-selectivity Nitrogen molecules, is an important issue in the field of new drug research and development.In the method of building carbon and nitrogen bonds, carbon-based nucleophiles attack imine carbon and nitrogen double bond bonding is a common method.If the imine carbon and nitrogen double bond polarity Reversal occurred,