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目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)治疗男性尿道口尖锐湿疣(CA)的疗效及治疗后局部病毒的清除情况。方法将入选的78例男性尿道口CA患者随机分为两组,治疗组42例,予以ALA-PDT治疗,对照组36例,予以高频电灼治疗,治疗后1周时判定疗效。并且在治疗前、后分别应用导流杂交基因芯片技术(简称HybrMiax)检测人乳头瘤病毒DNA(HPV-DNA)。结果治疗组和对照组的有效率分别为95.20%和100%,差异无统计学意义(P>0.05);治疗组(12.50%)与对照组(41.70%)的复发率、HPV清除率(分别为69.05%,22.22%)比较,差异均有统计学意义(P均<0.05)。结论 ALA-PDT治疗男性尿道口CA有效,复发率低,并且对尿道口局部的病毒清除作用优于传统的疗法。
Objective To observe the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of male urethral condyloma acuminatum (CA) and the removal of local virus after treatment. Methods Seventy-eight male urethral CA patients were randomly divided into two groups. The treatment group received 42 cases of ALA-PDT and the control group of 36 cases received high-frequency electrocautery. One week after treatment, the curative effect was evaluated. Before and after treatment, HPV DNA was detected by flow cytometry (HybrMiax). Results The effective rates of the treatment group and the control group were 95.20% and 100%, respectively, with no significant difference (P> 0.05). The recurrence rate and HPV clearance rate of the treatment group (12.50%) and the control group (41.70% 69.05%, 22.22%), the differences were statistically significant (all P <0.05). Conclusions ALA-PDT is effective and has a low recurrence rate in male urethral CA, and its local clearance of virus in the urethra is superior to traditional therapy.