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高血压病(EH)患者有多种细胞膜钙运转异常。本研究用原子吸收法测定红细胞膜结合钙含量发现:(1)EH组(48例)值明显低于对照组(35例);分别为2.16±0.87和4.65±1.39μg/mg膜蛋白(P<0.01)。(2)不同期的高血压即Ⅰ期(12例)、Ⅱ期(26例)和Ⅲ期(10例),也显示膜结合量不同,分别力3.21±0.37、2.20±0.3和0.82±0.25μg/mg膜蛋白(P<0.01)。膜钙与收缩压、舒张压和平均压呈负相关,r分别为-0.795、-0.797和-0.883(P均<0.01)。(3)本研究所用膜钙测定方法简便、实用。因而。我们认为,膜钙降低不但对高血压发病膜缺陷机理探讨有益,而且对了解高血压病的程度有一定价值。
Hypertension (EH) patients have a variety of cell membrane calcium abnormalities. In this study, we found that: (1) The values of EH group (48 cases) were significantly lower than those of the control group (35 cases); they were 2.16 ± 0.87 and 4.65 ± 1.39μg / mg respectively <0.01). (2) Hypertension in different stages, namely stage I (12 cases), stage II (26 cases) and stage III (10 cases), also showed different levels of membrane binding with 3.21 ± 0.37,2.20 ± 0.3 and 0.82 ± 0.25 μg / mg membrane protein (P <0.01). Membrane calcium was negatively correlated with systolic pressure, diastolic pressure and mean pressure, r were -0.795, -0.797 and -0.883, respectively (all P <0.01). (3) Membrane calcium assay used in this study is simple and practical. thus. We believe that membrane calcium is not only beneficial to explore the mechanism of membrane defects in hypertension, but also to understand the extent of hypertension is of some value.