论文部分内容阅读
目的研究太白乐胶囊(试验样品)对小鼠化学性肝损伤的辅助保护作用。方法随机将实验动物分为低、中、高(0.083 g/kg.bw、0.167 g/kg.bw和0.500 g/kg.bw)3个剂量组,分别灌胃给予对应剂量的试验样品,另设1个空白对照组和1个模型对照组,给予蒸馏水,连续30 d,试验末期3个剂量组和模型对照组按12 ml/kgBW一次灌胃50%乙醇造肝损伤模型,,制备小鼠肝匀浆并测定其中丙二醛(MDA)、还原型谷胱甘肽(GSH)、甘油三酯(TG)含量。结果与模型对照组比较,3个剂量组肝组织病理积分均明显降低,0.500 g/kg剂量组肝匀浆中的MDA含量明显降低,GSH含量显著升高,但所有剂量组肝匀浆中TG含量无明显差异。结论试验样品对化学性肝损伤有辅助保护作用。
Objective To study the protective effect of Taibaile capsule (test sample) on chemical liver injury in mice. Methods The experimental animals were randomly divided into three groups: low, middle and high doses (0.083 g / kg.bw, 0.167 g / kg.bw and 0.500 g / kg.bw) A blank control group and a model control group were given distilled water for 30 days, the end of the experimental three dose groups and model control group by 12 ml / kg BW once intragastric administration of 50% ethanol liver injury model mice were prepared Liver homogenate and determination of MDA, GSH and TG. Results Compared with the model control group, the histopathological scores of liver tissue in the three dose groups were significantly decreased. The content of MDA in the liver homogenate of 0.500 g / kg dose group decreased significantly and the content of GSH increased significantly. However, No significant difference in content. Conclusion The experimental samples have an auxiliary protective effect on chemical liver injury.