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目的了解肺炎衣原体(Chlamydia Pneumoniae,Cpn)感染与慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)的相关性。方法采用间接酶联免疫吸附实验室检测322例COPD病例和150例健康对照组特异性抗体IgG、IgM。结果肺炎衣原体在慢性阻塞性肺疾病组中有较高的检出率,与健康对照组之间的感染率具有统计学意义(P<0.05);COPD组与健康对照组的暴露比值比(odds ratio,OR)为8.2。结论Cpn血清特异性抗体IgG、IgM的升高与COPD有相关性,Cpn感染可能参与了其发病机制;Cpn的暴露对COPD的发生有较强的影响。
Objective To investigate the relationship between Chlamydia pneumoniae (Cpn) infection and Chronic Obstructive Pulmonary Disease (COPD). Methods Indirect ELISA was used to detect IgG and IgM in 322 COPD patients and 150 healthy controls. Results The positive rate of Chlamydia pneumoniae in chronic obstructive pulmonary disease group was significantly higher than that in healthy control group (P <0.05). The odds ratio (odds ratio ratio, OR) is 8.2. Conclusions The elevated CpG serum IgG and IgM are correlated with COPD. Cpn infection may play a role in its pathogenesis. Cpn exposure has a strong influence on the development of COPD.