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目的 探讨老年性耳聋SOD、MDA及红细胞变形性之间的关系 ,为临床上能有效地控制和延缓老年性耳聋的发生和发展提供依据。方法 测定 6 8例老年性耳聋病人和 5 0例健康老年人的血浆超氧化物歧化酶(SOD)和脂质过氧化产物丙二醛 (MDA)的水平及血液红细胞变形性。结果 老年性耳聋病人的SOD水平降低 ,MDA水平增高 ,红细胞变形能力降低 ,与健康对照组相比有极显著性差异 (P <0 .0 1) ,且SOD含量与红细胞变形能力呈正相关关系 (P <0 .0 1) ,与MDA含量呈负相关关系 (P <0 .0 1)。结论 老年性耳聋病人的SOD含量下降 ,红细胞变形能力降低 ,而丙二醛 (MDA)水平增高 ,建议在临床上对老年性耳聋病人应用增加SOD含量 ,提高红细胞变形能力 ,减少MDA含量的药物
Objective To explore the relationship between SOD, MDA and erythrocyte deformability in senile deafness, and to provide the basis for effectively controlling and delaying the occurrence and development of senile deafness in clinic. Methods Plasma levels of superoxide dismutase (SOD), malondialdehyde (MDA) and blood erythrocyte deformability in 68 elderly patients with senile deafness and 50 healthy controls were measured. Results The senile deafness patients had lower level of SOD, higher level of MDA and lower erythrocyte deformability compared with the healthy control group (P <0.01), and there was a positive correlation between SOD level and erythrocyte deformability P <0.01), but negatively correlated with MDA content (P <0.01). Conclusions The content of SOD, the ability of erythrocyte deformability and the level of malondialdehyde (MDA) in senile deafness patients are lower than those in the senile deafness patients. It is suggested that the clinical application should be made on the drugs that increase SOD content, improve erythrocyte deformability and decrease MDA content