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以钠、钙泵活性同步测定法检测9个有EH家族史家系中99名成员红细胞膜钠泵及钙泵活性,对照为67名健康人,并对其变异进行遗传分析。结果未见钠泵活性与EH的发生相关,其遗传关系也不明显。EH患者钙泵活性明显改变,受遗传因素控制,是垂直传递,为常染色体显性遗传。提示钙泵活性缺陷可能与EH发生有密切联系。
Ninety-nine members of EH family history pedigrees were tested for erythrocyte membrane sodium pump and calcium pump activity by sodium and calcium pump activity synchronous assay. The control group was 67 healthy people, and genetic variation was analyzed. Results No sodium pump activity associated with the occurrence of EH, the genetic relationship is not obvious. EH patients with significant changes in calcium pump activity, controlled by genetic factors, is vertical transmission, autosomal dominant inheritance. Tip calcium pump activity defects may be closely linked with the occurrence of EH.