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目的:探讨顺铂腹腔输注治疗卵巢癌的疗效与安全性,并与静脉输注治疗进行比较。方法:我院于1998年1月～2004年5月采用前瞻性对照研究方法,将13例卵巢上皮癌患者随机分为腹腔输注(8例)组及静脉输注(5例)组:结果:腹腔输注组疗效明显优于静脉输注组,两组的有效率为100%,但腹腔输注组的毒副反应明显低于静脉输注组。结论:顺铂腹腔输注治疗卵巢癌不仅疗效显著,而且能最大程度地减少药物毒副作用。
Objective: To investigate the efficacy and safety of intraperitoneal cisplatin in the treatment of ovarian cancer and compare with intravenous infusion. Methods: From January 1998 to May 2004, 13 patients with epithelial ovarian cancer were randomly divided into intraperitoneal infusion (n = 8) and intravenous infusion (n = 5) by a prospective controlled study: Results : Intraperitoneal infusion group was significantly better than the intravenous infusion group, the effective rate was 100% in both groups, but the toxicity of intraperitoneal infusion group was significantly lower than the intravenous infusion group. Conclusion: The cisplatin intraperitoneal infusion of ovarian cancer treatment is not only significant, but also to minimize the drug side effects.