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目的:研究Graves病(GD)患者胰岛素样生长因子-I(IGF-I)水平与甲状腺体积的关系。方法:用ELISA方法测定58例GD患者治疗前后血清IGF-I的含量,用多普勒超声测定甲状腺体积。用免疫组化和原位杂交法检测28例GD患者甲状腺组织IGF-I的表达。结果:GD患者治疗前血清IGF-I含量及甲状腺体积均高于正常对照(均P<0.01),治疗后血清IGF-I含量及甲状腺体积均下降(均P<0.01),但仍高于正常对照(均P<0.01);GD患者血清IGF-I含量同甲状腺体积呈正相关(r=0.57,P<0.01),血清IGF-I含量与FT3、FT4无关。IGF-I在GD患者甲状腺组织中的表达明显高于在正常甲状腺组织中的表达(P<0.05);GD手术治疗患者甲状腺组织IGF-I表达强度与术前甲状腺体积呈正相关(r=0.63,P<0.01)。结论:IGF-I水平与GD患者甲状腺体积有关。
Objective: To study the relationship between the level of insulin-like growth factor-I (IGF-I) and thyroid volume in patients with Graves disease (GD). Methods: The levels of serum IGF-I in 58 patients with GD before and after treatment were measured by ELISA. The thyroid volume was measured by Doppler echocardiography. The expression of IGF-I in thyroid tissue of 28 patients with GD was detected by immunohistochemistry and in situ hybridization. Results: Serum IGF-I levels and thyroid volume in patients with GD before treatment were significantly higher than those in normal controls (all P <0.01). The levels of serum IGF-I and thyroid volume were decreased in GD patients (all P <0.01) (All P <0.01). The serum IGF-I level in GD patients was positively correlated with the thyroid volume (r = 0.57, P <0.01). The serum IGF-I levels were not related to FT3 and FT4. The expression of IGF-I in thyroid tissue of patients with GD was significantly higher than that in normal thyroid tissue (P <0.05). The expression of IGF-I in thyroid tissue was positively correlated with the volume of thyroid before surgery (r = 0.63, P <0.01). Conclusion: The level of IGF-I is related to the thyroid volume in patients with GD.