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目的:探讨血清肌钙蛋白I(cTnI)、肌酸激酶同工酶MB(CK-MB)在急性心肌梗死(AMI)中的诊断价值。方法:采用化学发光法和免疫抑制法分别测定76例急性心肌梗死患者胸痛发生后4h、8h、12h、24h、48h以及第5天、第7天的血清,测定其血清肌钙蛋白I和肌酸激酶同工酶MB值,另测定40例健康者血清做正常对照组。结果:急性心肌梗死组血清肌钙蛋白I、肌酸激酶同工酶MB的阳性率明显高于健康组(采用胸痛12h后的血清测定值),分别和健康组相比差异具有显著性(P<0.01)。测定4h和第5天、第7天的血清肌钙蛋白I诊断急性心肌梗死的阳性率明显高于肌酸激酶同工酶MB。所以,血清肌钙蛋白I的测定在诊断急性心肌梗死中具有更高的灵敏度、更宽的诊断时间和高度特异性。
Objective: To investigate the diagnostic value of serum cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) in acute myocardial infarction (AMI). Methods: The chemiluminescence and immunosuppressive methods were used to determine the serum levels of serum troponin I and muscle in 76 patients with AMI at 4h, 8h, 12h, 24h, 48h and 5d and 7d after chest pain. Acid kinase isozyme MB value, the other 40 cases of healthy persons were measured serum as a normal control group. Results: The positive rates of serum cardiac troponin I and creatine kinase MB in acute myocardial infarction group were significantly higher than those in healthy group (measured after 12 hours of chest pain), there was significant difference compared with healthy group (P <0.01). The positive rates of Serum troponin I for diagnosis of acute myocardial infarction at 4h, 5th day and 7th day were significantly higher than that of creatine kinase MB. Therefore, the determination of serum troponin I in the diagnosis of acute myocardial infarction with a higher sensitivity, a longer diagnostic time and a high degree of specificity.