【摘 要】
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MicroRNA alterations have been reported in patients with Alzheimer ’s disease(AD) and AD mouse models. We now report that miR-206 is upregulated in the hippoca
【机 构】
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Beijing Obstetrics & Gynecology Hospital, Capital Medical University,The High School affi liated to
【出 处】
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Neuroscience Bulletin
论文部分内容阅读
MicroRNA alterations have been reported in patients with Alzheimer ’s disease(AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor(BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specifi c microRNA alteration may contribute to AD pathology by downregulating BDNF.
MicroRNA alterations have been reported in patients with Alzheimer’s disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP / PS1 transgenic mice. The increased miR -206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP / PS1 mice it is decreased. Thus, a specifi c microRNA alteration may contribute to AD pathology by downregulating BDNF.
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