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本文以较低剂量(5和20mg/kg)的醋酸铅对恒河猴进行重复二次染毒,实验结果表明,动物中毒表现不明显,但铅特异指标如PbB、FEP、ZnPP和δ-ALAD等含量已发生明显的改变。血清钙含量在染毒前、后无显著差异。两次染毒猴子对铅的吸收速率基本一致,第二阶段染毒停止后PbB水平恢复要慢于第一阶段,提示铅蓄积随染毒时间、频率而增加。在本实验剂量下,主要引起机体铅蓄积和铅接触指标的变化。此外,由于长期接触尚可能造成部分脏器的功能异常。
In this paper, rhesus monkeys were treated with repeated doses of lead acetate at lower doses (5 and 20 mg / kg). The results showed that animal poisoning was not obvious, but Pb-specific indicators such as PbB, FEP, ZnPP and δ-ALAD The content has changed significantly. Serum calcium content before and after exposure was no significant difference. The rates of Pb absorption in the two infected monkeys were basically the same. The recovery of PbB in the second phase was slower than that in the first phase, suggesting that the accumulation of lead increased with the time and frequency of exposure. In the experimental dose, the main cause of lead body lead accumulation and changes in lead exposure. In addition, due to prolonged exposure may still cause some organ dysfunction.