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Objective: To observe the efficacy of Astragalus Polygonum Anti Fibrosis decoction (APAFD)and Jinshuibao capsule (JSBC) in treating liver fibrosis of chronic hepatitis B. Methods: Ninety two cases of liver fibrosis of chronic hepatitis B were randomly divided into group A and group B. Patients in group A received APAFD for 48 weeks, and in group B, they received JSBC for 48 weeks. The effects on the level change of hyaluronic acid (HA), laminin (LN), pro collagen Ⅲ (PCⅢ) and collagen Ⅳ (CⅣ) as well as liver functional tests and liver biochemical parameters before and after treatment were observed.Results: Level of serum HA, LN, PCⅢ and CⅣ in group A declined more obviously than that of group B, the difference was significant ( P <0.01). The liver functional tests such as total bilirubin (TB), alanine aminotransferase (ALT), albumin/globulin (A/G) ratio, hepatitis related serum biochemical parameters such as cholylglycine (CG), serum ferritin (SF), prealbumin (PC) of group A were all improved more significantly than that of group B ( P <0.01).Conclusion: APAFD is more effective than JSBC in treating liver fibrosis of chronic hepatitis B and in the inhibition of hepatic inflammation, hence it is a good composite Chinese herbal preparation against liver fibrosis.
Objective: To observe the efficacy of Astragalus Polygonum Anti Fibrosis decoction (APAFD) and Jinshuibao capsule (JSBC) in treating liver fibrosis of chronic hepatitis B. Methods: Ninety two cases of liver fibrosis of chronic hepatitis B were randomly divided into groups A and group B. patients in group received APAFD for 48 weeks, and in group B, they received JSBC for 48 weeks. The effects on the level change of hyaluronic acid (HA), laminin (LN), pro collagen III (PCIII) and collagen (CIV) as well as liver functional tests and liver biochemical parameters before and after treatment were observed. Results: Level of serum HA, LN, PCIII and C IV in group A declined more obviously than that of group B, the difference was significant ( The liver functional tests such as total bilirubin (TB), alanine aminotransferase (ALT), albumin / globulin (A / G) ratio, hepatitis related serum biochemical parameters such as cholylglycine (CG), serum ferritin (SF) , prealbumin (PC) of group A were all improved more significantly than that of group B (P <0.01) .Conclusion: APAFD is more effective than JSBC in treating liver fibrosis of chronic hepatitis B and in the inhibition of hepatic inflammation, hence it is a good composite Chinese herbal preparation against liver fibrosis.