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目的探讨霉酚酸酯(MMF)对狼疮性肾炎(LN)患者的动脉粥样硬化指数(AI)及颈动脉内膜-中膜厚度(IMT)的影响。方法 45例LN患者用MMF治疗(MMF组,23例)和环磷酰胺(CTX)治疗(CTX组,22例),比较治疗前后AI、IMT和系统性红斑狼疮疾病活动性指数(SLE-DAI)的变化。结果两组治疗前后的IMT、AI和SLE-DAI比较差异均无统计学意义(P>0.05)。MMF组和CTX组治疗缓解率分别为81.8%和69.6%(P>0.05)。缓解病例治疗前后IMT变化值明显小于未缓解病例(P<0.05)。结论 MMF治疗LN的1年疗效与CTX相仿;LN病情控制者的IMT增厚明显减慢。
Objective To investigate the effects of mycophenolate mofetil (MMF) on atherosclerosis index (AI) and carotid intima - media thickness (IMT) in patients with lupus nephritis (LN). Methods 45 LN patients were treated with MMF (23 cases) and CTX (CTX group, 22 cases). The AI, IMT and systemic lupus erythematosus SLE-DAI )The change. Results There was no significant difference in IMT, AI and SLE-DAI between the two groups before and after treatment (P> 0.05). The response rates of MMF group and CTX group were 81.8% and 69.6%, respectively (P> 0.05). The changes of IMT before and after treatment were significantly lower than those without remission (P <0.05). Conclusions The 1-year efficacy of MMF in treating LN is similar to that of CTX. The IMT thickening of LN patients is obviously slowed down.