HIV-1感染病人B 细胞的激活AIDS 流行后即发现患者B 细胞功能异常;最明显的是高丙球蛋白血症、循环中活化B 细胞数增加、出现自身抗体及对其它病原体的抗体滴度升高。最近在HIV-1感染者血清中测出了抗淋巴细胞抗体,它能识别活化的和HIV-1感染CD_4~+T 细胞表面上的18KDa 抗原,但它们与病毒无反应。体外Ig 的自发合成是血清阳性者的显著 Activation of B cells in HIV-1 infected patients Found that patients with B cell dysfunction after the epidemics; the most obvious is hypergammaglobulinemia, circulating activated B cells increased, autoantibodies and antibody titers to other pathogens increased . Recently, anti-lymphocyte antibodies were detected in the sera of HIV-1 infected patients, which recognize 18 kDa antigens on the surface of activated and HIV-1 infected CD 4 + T cells, but they are non-reactive with the virus. Spontaneous synthesis of Ig in vitro is significant in seropositive individuals