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目的设计一种经皮经肝途径置入可携带放射性粒子的胆道引流导管,以达到胆汁引流和胆道腔内放疗的双重效果,用于治疗恶性胆道梗阻。方法利用常用的导管制作材料聚氨酯,通过铸型加热拉管技术,形成具有3腔结构的导管,导管外径8~10 F,3个腔内径分别为0.75 mm、0.75 mm和≥1 mm,其中≥1 mm内径的管腔作为胆汁引流的通道,2个0.75 mm的管腔做为承载125I粒子的通道。对导管尾端进行特殊设计,便于粒子的置入及引流袋的连接。结果开发研制的胆道粒子引流导管结构合理,125I粒子假源能顺利送入导管的粒子腔道内,电视透视观察粒子能连续排列形成粒子链,并保持不移位;导管引流腔道与尾端引流接口相通,能够保证胆汁的顺利流出。结论本研究研制的导管具有较好的引流效果同时可携带125I粒子,拟对呈线形排列的粒子链的剂量学及生物效应进行计算,通过动物实验进一步探索其介入操作可行性及安全性。
Objective To design a percutaneous transhepatic approach for the placement of biliary drainage catheters that can carry radioactive particles in order to achieve the dual effects of biliary drainage and biliary cavity radiotherapy for the treatment of malignant biliary obstruction. Methods The commonly used catheter was used to make the material polyurethane. The catheter was heated by the mold heating to form a catheter with a 3-cavity structure. The external diameter of the catheter was 8 ~ 10 F, and the internal diameters of 3 cavities were 0.75 mm, 0.75 mm and ≥1 mm, The lumens ≥1 mm in internal diameter serve as the passage for the bile drainage and two 0.75 mm lumens serve as the passage for the 125I particles. The tail end of the catheter is specially designed to facilitate the placement of the particles and the connection of the drainage bag. Results The developed biliary tract drainage catheter has a reasonable structure. The 125I particle pseudo-source can be smoothly delivered into the particle cavity of the catheter. The particles can be continuously arranged to form the particle chain by TV fluoroscopy and remain unchanged. The drainage channel and caudal drainage Interface connected to ensure the smooth flow of bile. Conclusions The catheter developed in this study has good drainage effect and can carry 125I particles. The dosimetry and biological effects of linearly arranged particle chains are to be calculated. The feasibility and safety of interventional experiments are further explored through animal experiments.