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为探讨肝性脑病是否存在脑器质性损害及脑脊液SOD含量测定对脑损害程度的估计价值,将对照组、单纯肝硬化、亚临床肝性脑病、肝性脑病及有脑器质性损害患者分5组作脑脊液SOD含量的测定。结果发现肝性脑病组脑脊液SOD含量为996.10±228.52μg/L,较对照组和单纯肝硬化组明显增高(P<0.01),并与脑器质性损害组(974.51±389.28μg/L)接近(P>0.05)。亚临床肝性脑病患者脑脊液SOD含量805.00±276.53μg/L,明显高于对照组(P<0.05),但低于肝性脑病患者(P<0.05)。表明肝性脑病存在脑器质性损害。脑脊液SOD含量的测定对评估脑损害严重程度有一定价值。
To investigate the existence of organic encephalopathy in rats with hepatic encephalopathy and the estimated value of cerebrospinal fluid SOD content in evaluating the degree of brain damage, the control group, cirrhosis, subclinical hepatic encephalopathy, hepatic encephalopathy and patients with organic brain damage Divided into 5 groups for determination of cerebrospinal fluid SOD content. The results showed that the content of SOD in cerebrospinal fluid of the patients with hepatic encephalopathy was 996.10 ± 228.52μg / L, which was significantly higher than that of the control group and the simple cirrhosis group (P <0.01) and was close to that of the organic damage group (974.51 ± 389.28μg / L) (P> 0.05). The content of SOD in cerebrospinal fluid of patients with subclinical hepatic encephalopathy was 805.00 ± 276.53μg / L, which was significantly higher than that of the control group (P <0.05), but lower than that of patients with hepatic encephalopathy (P <0.05). That hepatic encephalopathy organic brain damage. Determination of cerebrospinal fluid SOD content to assess the severity of brain damage have a certain value.