抗心律失常药物和洋地黄均为临床常用药物,但对两者间的相互作用一直未引起足够的重视。近年来,随着血清地高辛浓度(serum digoxin concentration,SDC)检测方法的广泛应用,有关抗心律失常药物和洋地黄相互作用的报道日益增多。本文综述合理应用这些药物的有关理论资料。临床资料奎尼丁 1978年,Leahey等首次发现奎尼丁可引起SDC持续升高,作者在92例同时口服地高辛和奎尼丁的患者中,选择27例加服奎 Antiarrhythmic drugs and digitalis are clinically used drugs, but the interaction between the two has not been given enough attention. In recent years, with the extensive application of serum digoxin concentration (SDC) detection methods, the reports on the interaction between antiarrhythmic drugs and digitalis have been increasing. This article reviews the rationale for the rational use of these drugs. Clinical data Quinidine 1978, Leahey and other first discovered that quinidine can cause persistent SDC, the authors in 92 patients with simultaneous oral administration of digoxin and quinidine, choose 27 cases plus serotonin