应激状态下ＨＰＡ轴功能亢进与中枢神经系统有着十分密切的联系，一方面，应激反应可促进中枢儿茶酚胺（ＣＡ）和兴奋性氨基酸（ＥＡＡＳ）的释放，另一方面下丘脑去甲肾上腺素（ＮＡ）和ＥＡＡＳ可提高ＨＰＡ轴兴奋性，增强ＨＰＡ轴对应激原的反应 Stress state of HPA axis hyperthyroidism and the central nervous system are closely linked, on the one hand, the stress response can promote central catecholamine (CA) and excitatory amino acids (EAAS) release, on the other hand hypothalamic norepinephrine (NA) and EAAS increase the HPA axis excitability and enhance the HPA axis response to stressors