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近年发现,维生素B_6(以下简称B_6)有许多新的临床用途。现介绍如下。一、抢救异烟肼中毒:异烟肼中毒的病人常发生严重抽搐,而B_6有促进抑制性神经递质r-氨基丁酸合成和控制抽搐作用,因而可用来解毒。有人用B_6抢救异烟肼中毒19例,12例痊愈,7例因B_6剂量不足死亡。用法:每服1.0g异烟肼静注B_6 1.0g;如不知中毒量,可先用B_6 5.0g在3～5分钟内缓慢静注,必要时可间隔5～20分钟重复注射,直至抽搐停止,意识恢复。二、防治妊娠糖尿病:孕妇易缺乏B_6而引起色氨酸代谢异常,产生黄尿酸—胰岛素复合物,使胰岛素的降糖作用明显减弱而
In recent years, vitamin B_6 (hereinafter referred to as B_6) has many new clinical uses. Now introduced as follows. First, rescue isoniazid poisoning: Isoniazid poisoning patients often have severe convulsions, and B_6 can promote the inhibitory neurotransmitter r-aminobutyric acid synthesis and control of twitch effect, which can be used to detoxify. B_6 was used to rescue 19 cases of isoniazid poisoning, 12 patients recovered, 7 patients died of insufficient doses of B_6. Usage: each serving 1.0g isoniazid intravenous injection B_6 1.0g; If I do not know the amount of poisoning, can be used B_6 5.0g in 3 to 5 minutes slowly intravenously, if necessary, 5 to 20 minutes intervals repeated injections until the convulsions stop Consciousness recovery. Second, the prevention and treatment of gestational diabetes: Pregnant women prone to the lack of B_6 caused by abnormal tryptophan metabolism, resulting in yellow uric acid - insulin complex, so that the hypoglycemic effect of insulin was significantly reduced