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目的 通过与PET/CT在病灶检测及定量分析方面的比较,论证PET/MR一体机应用于临床的可行性.方法 2012年5月至2013年2月共300例患者同天间隔15 ～ 35 min行PET/CT和PET/MR检查,其中临床及影像学资料完整的277例[男165例,女112例,平均年龄(52.9±12.6)岁]纳入该研究.扫描范围由下颌至大腿根部.PET/CT采集为2或3 min/床位,PET/MR采集为5 min/床位,MRI图像包括T1、T2及弥散加权成像,图像重建采用Vender软件及MRI散射校正Mu图.PET、CT、MRI中只要有1项为阳性,即认为PET/CT及PET/MR的结果为阳性.勾画ROI并计算SUVmax..不同显像技术间探测效率的比较采用配对x2检验,并对PET/CT与PET/MR的SUVmax进行相关分析.结果 277例患者随访证实阳性220例,病灶353个.与PET/CT比,PET/MR少发现了6个病灶,但多发现了30个病灶.两者的探测效率差异有统计学意义(P＜0.05).以病灶和患者计,两者的一致性分别为89.8％(317/353)和85.9％ (189/220).相同部位病灶PET/CT和PET/MR的SUVmax.的相关性良好(rs=0.91,P＜0.01),多数正常组织(除肺和主气管)的SUVmax.也具有良好的相关性(rs=0.62～0.76,均P＜0.01).结论 PET/MR一体机在半定量分析方面与PET/CT有良好的相关性,在躯干部尤其是腹、盆腔病变及软组织病变检测方面优于PET/CT,可以为临床提供可靠的影像学诊断.“,”Objective To verify the feasibility of the integrated PET/MR for oncological applications by comparing PET/MR with PET/CT in terms of lesion detection and quantitative measurement.Methods A total of 277 patients (165 males,112 females,average age (52.9± 12.6) years) voluntarily participated in this same-day PET/CT and PET/MR comparative study.The time interval between the two studies was 15-35 min.PET/CT images were acquired and reconstructed following standard protocols.PET/MR covered the body trunk with a sequence combination of transverse T1 weighted imaging (WI) 3D-volumetric interpolated breath-hold,T2WI turbo spin echo with fat saturation,diffusion-weighted imaging,and simultaneous PET acquisition.PET images were reconstructed by vender-provided attenuation correction methods.The results of PET/CT and PET/MR were regarded as positive if any modality (CT,PET or MRI) was positive.SUVmax was obtained by the manually drawn ROI.Detection rates were compared with x2 test and SUVmax from the two modalities was analyzed with Spearman correlation analysis.Results A total of 353 lesions were detected in 220 patients.Compared to PET/CT,PET/MR revealed 30 additional true-positive lesions,while missed 6.The detection rates between PET/CT and PET/MR were significantly different (P＜0.05).The lesion-based and patient-based consistency was 89.8％ (317/353) and 85.9％ (189/220),respectively.There were significant correlations of SUVmax between PET/MR and PET/CT for lesions(rs =0.91,P＜0.01) and for normal tissues(rs =0.62-0.76,all P＜0.01).Conclusions With reference to PET/CT,integrated PET/MR may provide comparable semi-quantitative measurements of pathological lesions as well as normal tissues.Integrated PET/MR may be more effective to detect lesions in abdomen and pelvis.