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目的 :观察银杏叶提取物 ( GBE)对 型糖尿病 ( DM)患者血浆氧化修饰低密度脂蛋白 ( Ox-L DL)水平的影响。方法 :选择 型 DM及正常对照组各 30例。DM组口服银杏叶治疗 ,用药前后测定 Ox- L DL、丙二醛 ( MDA)、过氧化物歧化酶 ( SOD)、空腹血糖 ( FBS)、空腹血胰岛素 ( INS)、糖化血红蛋白 ( Hb Alc)和血脂 ( CH、TG)。结果 : 型 DM血浆 Ox- LDL、MDA水平明显高于对照组 ,而 SOD活力低于对照组。 型 DM组血浆 Ox- L DL、MDA在用药 4周后较前有明显下降 ( P<0 .0 1) ,同时影响血脂水平 ( P<0 .0 5) ;SOD活力和糖代谢指标在用药前后差异不显著。结论 :Ox-L DL在 型 DM的动脉粥样硬化过程中可能发挥重要作用 ;GBE具有良好抗氧化效果 ,对防治DM的血管病变有积极的意义。
Objective: To observe the effect of ginkgo biloba extract (GBE) on plasma oxidized low density lipoprotein (Ox-L DL) in type 2 diabetic patients. Methods: Select type DM and normal control group, 30 cases each. DM group was treated with ginkgo biloba. OxLDL, malondialdehyde (MDA), superoxide dismutase (SOD), fasting blood glucose (FBS), fasting insulin (INS), glycosylated hemoglobin (HbAc) And lipids (CH, TG). Results: The levels of Ox-LDL and MDA in type DM plasma were significantly higher than those in control group, while the activity of SOD was lower than that in control group. The levels of Ox-LDL and MDA in DM group decreased significantly (P <0.01) after 4 weeks of treatment, and also affected the level of blood lipid (P <0.05). SOD activity and glucose metabolism index Before and after the difference was not significant. Conclusion: Ox-L DL may play an important role in atherosclerosis of type DM. GBE has a good anti-oxidant effect and has a positive effect on the prevention and treatment of DM.