大环内酯类抗生素红霉素广泛用于临床,本文作者研究了正常人和酒精性肝病患者的红霉素的代谢动力学。研究对象是6名(4男2女)经内科检查在血液、肝、肾系统均正常的成人和6名男性患酒精性肝病的受试者,他们经组织活检确诊为肝硬化或有酗酒继发肝病的临床体征和症状。正常受试者静注相当于红霉素硷500mg的乳糖酸盐或口服红霉素硷500mg,酒精性肝病受试者只口服红霉素硷500mg。给药后的不同时间抽取血样,分离血清,用微生物 The macrolide antibiotic erythromycin is widely used clinically and the authors investigated the erythromycin pharmacokinetics in normal and alcoholic liver disease patients. The subjects were 6 adults (4 males and 2 females) who underwent medical examination of adults with normal blood, liver and kidney systems and 6 men with alcohol-induced liver disease who had been diagnosed with cirrhosis or alcoholism by biopsy Clinical signs and symptoms of liver disease. Normal subjects intravenously equivalent to erythromycin 500mg lactose or oral erythromycin 500mg, alcoholic liver disease subjects only oral erythromycin 500mg. Blood samples were taken at different times after administration, serum was separated, and microbes were used